ZhETF, Vol. 132,
No. 4,
p. 978 (October 2007)
(English translation - JETP,
Vol. 105, No. 4,
p. 856,
October 2007
available online at www.springer.com
)
KINETIC MODEL OF HIV INFECTION
Zhdanov V.P.
Received: April 23, 2007
PACS: 87.18.-h, 87.19.Xx, 87.10.+e
The recent experiments clarifying the details of exhaustion of the CD8 T cells specific to various strains of human immunodeficiency virus (HIV) are indicative of slow irreversible (on the one-year time scale) deterioration of the immune system. The conventional models of HIV kinetics do not take this effect into account. Removing this shortcoming, we show the likely influence of such changes on the HIV escape from control of the immune system.
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